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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medparasitology</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская паразитология и паразитарные болезни</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Parasitology and Parasitic Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0025-8326</issn><issn pub-type="epub">2713-1777</issn><publisher><publisher-name>Научно-образовательный паразитологический центр им. П.Г. Сергиева</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33092/0025-8326mp2025.3.36-43</article-id><article-id custom-type="elpub" pub-id-type="custom">medparasitology-16</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИАГНОСТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DIAGNOSTICS</subject></subj-group></article-categories><title-group><article-title>Гистологический метод в диагностике эхинококкозов</article-title><trans-title-group xml:lang="en"><trans-title>Histological method in the diagnosis of echinococcosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федянина</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedyanina</surname><given-names>L. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimova</surname><given-names>M. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanova</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitriev</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет); ГБУ «Научно-исследовательский институт организации здравоохранения и медицинского менеджмента Департамента здравоохранения города Москвы» (НИИОЗММ ДЗМ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation; State Виdgetary Institution «Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Departament»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>21</day><month>04</month><year>2026</year></pub-date><volume>0</volume><issue>3</issue><fpage>36</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Научно-образовательный паразитологический центр им. П.Г. Сергиева, 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Научно-образовательный паразитологический центр им. П.Г. Сергиева</copyright-holder><copyright-holder xml:lang="en">Научно-образовательный паразитологический центр им. П.Г. Сергиева</copyright-holder><license xlink:href="https://www.medparasitology.com/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.medparasitology.com/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.medparasitology.com/jour/article/view/16">https://www.medparasitology.com/jour/article/view/16</self-uri><abstract><p>Диагностика эхинококкозов включает комплекс клинико-инструментальных и лабораторных методов. Однако многие новейшие высокоточные методы доступны только лабораториям крупных исследовательских центров. Большинство КДЛ ставит (подтверждает) диагноз на основании микроскопии пунктатов, гистосрезов и результатов иммуноферментного анализа (ИФА). Обсуждается проблема лабораторной диагностики эхинококкозов и доказательность рутинных методов КДЛ для дифференциальной диагностики Echinococcus granulosus и Echinococcus multilocularis.</p></abstract><trans-abstract xml:lang="en"><p>Diagnosis of echinococcosis includes a complex of clinical, instrumental and laboratory methods. However, many of the latest high-precision methods are available only to the laboratories of large research centers. The majority of CdLS make (confirm) the diagnosis based on microscopy of punctures, histosections and the results of enzyme immunoassay (ELISA). The problem of laboratory diagnosis of echinococcosis and the evidence of routine CDL methods for the differential diagnosis of Echinococcus granulosus and Echinococcus multilocularis are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лабораторная диагностика</kwd><kwd>гистологический метод</kwd><kwd>Echinococcus granulosus</kwd><kwd>Echinococcus (Аlveococcus) multilocularis. хитиновая и герминативная оболочки</kwd><kwd>протосколексы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>laboratory diagnostics</kwd><kwd>histological method</kwd><kwd>Echinococcus granulosus</kwd><kwd>Echinococcus (Alveococcus) multilocularis. chitinous and germinal shells</kwd><kwd>protoscoleces</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бронштейн А. М., Токмалаев А. К. Паразитарные болезни человека. Протозоозы и гельминтозы. М.: РУДН, 2002:75-183.</mixed-citation><mixed-citation xml:lang="en">Bronstein A. M., Tokmalayev A. K. Parasitic Diseases of Humans. Protozooses and Helminthoses. Moscow: RUDN, 2002:75-183. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Сергиев В.П., Лобзин Ю.В., С.С. Козлов. Паразитарные болезни человека: (протозоозы и гельминтозы): Руководство для врачей / под ред. В.П. Сергиева, Ю.В. Лобзина, С.С. Козлова. Петербург: ООО "Издательство Фолиант". 2016: 306-331.</mixed-citation><mixed-citation xml:lang="en">Human parasitic diseases: (protozooses and helminthiases): A guide for doctors / Ed. V. P. Sergiev, Yu. V. Lobzin, S. S. Kozlov. St. Petersburg: Foliant Publishing LLC, 2016 Pp. 306-331 (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Sioutis S, Reppas L, Bekos A, Soulioti E, Saranteas T, Koulalis D, Sapkas G, Mavrogenis AF. Echinococcosis of the spine. EFORT Open Rev. 2021 Apr 1;6(4):288-296. doi: 10.1302/20585241.6.200130. PMID: 34040806; PMCID: PMC8142696.</mixed-citation><mixed-citation xml:lang="en">Sioutis S, Reppas L, Bekos A, Soulioti E, Saranteas T, Koulalis D, Sapkas G, Mavrogenis AF. Echinococcosis of the spine. EFORT Open Rev. 2021 Apr 1;6(4):288-296. doi: 10.1302/20585241.6.200130. PMID: 34040806; PMCID: PMC8142696.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Abulaiti Y, Kadi A, Tayier B, et al. Primary pelvic Echinococcus granulosus infection: A case report. World J Clin Cases. 2023;11(17):40844089. doi:10.12998/wjcc.v11.i17.4084.</mixed-citation><mixed-citation xml:lang="en">Abulaiti Y, Kadi A, Tayier B, et al. Primary pelvic Echinococcus granulosus infection: A case report. World J Clin Cases. 2023;11(17):40844089. doi:10.12998/wjcc.v11.i17.4084.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Akrim Y, Barkate K, Arrad Y, Ghannane H, El Hakkouni A. Multiple Cerebral Hydatid Cysts: A Case Report. Cureus. 2022;14(5):e25529. Published 2022 May 31. doi:10.7759/cureus.25529.</mixed-citation><mixed-citation xml:lang="en">Akrim Y, Barkate K, Arrad Y, Ghannane H, El Hakkouni A. Multiple Cerebral Hydatid Cysts: A Case Report. Cureus. 2022;14(5):e25529. Published 2022 May 31. doi:10.7759/cureus.25529.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Liu H, Xie Y, An X, et al. Advances in Novel Diagnostic Techniques for Alveolar Echinococcosis. Diagnostics (Basel). 2025;15(5):585. Published 2025 Feb 27. doi:10.3390/diagnostics15050585.</mixed-citation><mixed-citation xml:lang="en">Liu H, Xie Y, An X, et al. Advances in Novel Diagnostic Techniques for Alveolar Echinococcosis. Diagnostics (Basel). 2025;15(5):585. Published 2025 Feb 27. doi:10.3390/diagnostics15050585.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Barth TFE, Casulli A. Morphological Characteristics of Alveolar and Cystic Echinococcosis Lesions in Human Liver and Bone. Pathogens. 2021;10(10):1326. Published 2021 Oct 14. doi:10.3390/pathogens10101326.</mixed-citation><mixed-citation xml:lang="en">Barth TFE, Casulli A. Morphological Characteristics of Alveolar and Cystic Echinococcosis Lesions in Human Liver and Bone. Pathogens. 2021;10(10):1326. Published 2021 Oct 14. doi:10.3390/pathogens10101326.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zewude RT, Corbeil A, Fung S, Moulton CA, Bogoch II. Alveolar Echinococcus in a 70-yearold man in Ontario. J Assoc Med Microbiol Infect Dis Can. 2024;8(4):336-342. Published 2024 Jan 16. doi:10.3138/jammi-2023-0012.</mixed-citation><mixed-citation xml:lang="en">Zewude RT, Corbeil A, Fung S, Moulton CA, Bogoch II. Alveolar Echinococcus in a 70-yearold man in Ontario. J Assoc Med Microbiol Infect Dis Can. 2024;8(4):336-342. Published 2024 Jan 16. doi:10.3138/jammi-2023-0012.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Государственный доклад «О состоянии санитарно-эпидемиологического благополучия населения Российской Федерации в 2022 году» https://rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=25076</mixed-citation><mixed-citation xml:lang="en">State Report on the State of Sanitary and Epidemiological Welfare of the Population of the Russian Federation in 2022 (in Russian) https://rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=25076</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Государственный доклад «О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2023 году» https://rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=27779</mixed-citation><mixed-citation xml:lang="en">State Report on the State of Sanitary and Epidemiological Welfare of the Population of the Russian Federation in 2023 (in Russian) https://rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=27779</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">МУК 4.2.3145-13. Лабораторная диагностика гельминтозов и протозоозов: Методические указания / Федеральный центр гигиены и эпидемиологии Роспотребнадзора. – 2014:23-24.</mixed-citation><mixed-citation xml:lang="en">MUK 4.2.3145-13. Parasitological methods of laboratory diagnostics of helminthiases and protozooses. M.: Federal Center of the State Sanitary and Epidemiological Supervision of the Ministry of Health of Russia, 2014 – 23-24 p. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Сергиев В. П. Атлас клинической паразитологии и тропической медицины. Москва: Авторская акад.: Товарищество научных изданий КМК, 2010:137-145.</mixed-citation><mixed-citation xml:lang="en">Atlas of Clinical Parasitology and Tropical Medicine. V.P. Sergiev. Moscow: Author's academician: Association of scientific publications KMK, 2010 P. 173 (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Biava MF, Dao A, Fortier B. Laboratory diagnosis of cystic hydatic disease. World J Surg 2001;25:10–14.</mixed-citation><mixed-citation xml:lang="en">Biava MF, Dao A, Fortier B. Laboratory diagnosis of cystic hydatic disease. World J Surg 2001;25:10–14.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Carmena D., Benito A., Eraso E. The immunodiagnosis of echinococcus multilocularis infection. Clin. Microbiol. Infect. 2007;13:460–475. doi: 10.1111/j.1469-0691.2007.01665.x.</mixed-citation><mixed-citation xml:lang="en">Carmena D., Benito A., Eraso E. The immunodiagnosis of echinococcus multilocularis infection. Clin. Microbiol. Infect. 2007;13:460–475. doi: 10.1111/j.1469-0691.2007.01665.x.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yang S.K., Zhang W., Zhu N., McManus D.P., Gray D.J., Clements A.C.A., Cadavid Restrepo A.M., Williams G.M., Zhang T., Ma G.R., et al. Serological comparison of native antigen ELISAs with rapid ICT test kits for the diagnosis of human alveolar and cystic echinococcosis in China. Trop. Med. Infect. Dis. 2024;9:44. doi: 10.3390/tropicalmed9020044.</mixed-citation><mixed-citation xml:lang="en">Yang S.K., Zhang W., Zhu N., McManus D.P., Gray D.J., Clements A.C.A., Cadavid Restrepo A.M., Williams G.M., Zhang T., Ma G.R., et al. Serological comparison of native antigen ELISAs with rapid ICT test kits for the diagnosis of human alveolar and cystic echinococcosis in China. Trop. Med. Infect. Dis. 2024;9:44. doi: 10.3390/tropicalmed9020044.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ito A., Nakao M., Sako Y. Echinococcosis: Serological detection of patients and molecular identification of parasites. Future Microbiol. 2007;2:439–449. doi: 10.2217/17460913.2.4.439.</mixed-citation><mixed-citation xml:lang="en">Ito A., Nakao M., Sako Y. Echinococcosis: Serological detection of patients and molecular identification of parasites. Future Microbiol. 2007;2:439–449. doi: 10.2217/17460913.2.4.439.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ito A., Xiao N., Liance M., Sato M.O., Sako Y., Mamuti W., Ishikawa Y., Nakao M., Yamasaki H., Nakaya K., et al. Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: Results of a blind test. J. Clin. Microbiol. 2002;40:4161–4165. doi: 10.1128/JCM.40.11.4161-4165.2002.</mixed-citation><mixed-citation xml:lang="en">Ito A., Xiao N., Liance M., Sato M.O., Sako Y., Mamuti W., Ishikawa Y., Nakao M., Yamasaki H., Nakaya K., et al. Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: Results of a blind test. J. Clin. Microbiol. 2002;40:4161–4165. doi: 10.1128/JCM.40.11.4161-4165.2002.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Tappe D., Grüner B., Kern P., Frosch M. Evaluation of a commercial echinococcus Western blot assay for serological follow-up of patients with alveolar echinococcosis. Clin. Vaccine Immunol. 2008;15:1633–1637. doi: 10.1128/CVI.00272-08.</mixed-citation><mixed-citation xml:lang="en">Tappe D., Grüner B., Kern P., Frosch M. Evaluation of a commercial echinococcus Western blot assay for serological follow-up of patients with alveolar echinococcosis. Clin. Vaccine Immunol. 2008;15:1633–1637. doi: 10.1128/CVI.00272-08.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sako Y., Fukuda K., Kobayashi Y., Ito A. Development of an immunochromatographic test to detect antibodies against recombinant Em18 for diagnosis of alveolar echinococcosis. J. Clin. Microbiol. 2009;47:252–254. doi: 10.1128/JCM.01476-08.</mixed-citation><mixed-citation xml:lang="en">Sako Y., Fukuda K., Kobayashi Y., Ito A. Development of an immunochromatographic test to detect antibodies against recombinant Em18 for diagnosis of alveolar echinococcosis. J. Clin. Microbiol. 2009;47:252–254. doi: 10.1128/JCM.01476-08.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Sako Y., Tappe D., Fukuda K., Kobayashi Y., Itoh S., Frosch M., Grüner B., Kern P., Ito A. Immunochromatographic test with recombinant Em18 antigen for the follow-up study of alveolar echinococcosis. Clin. Vaccine Immunol. 2011;18:1302–1305. doi: 10.1128/CVI.05156-11.</mixed-citation><mixed-citation xml:lang="en">Sako Y., Tappe D., Fukuda K., Kobayashi Y., Itoh S., Frosch M., Grüner B., Kern P., Ito A. Immunochromatographic test with recombinant Em18 antigen for the follow-up study of alveolar echinococcosis. Clin. Vaccine Immunol. 2011;18:1302–1305. doi: 10.1128/CVI.05156-11.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Demirkazık M., Koltas İ.S., İnceboz T., Korkmaz M., Gümürdülü D. Use of the ELISA (Em2-Em18) and Western blotting methods on diagnosis of alveolar echinococcosis. Turkiye Parazitol. Derg. 2019;43:13–17. doi: 10.4274/tpd.galenos.2019.6447.</mixed-citation><mixed-citation xml:lang="en">Demirkazık M., Koltas İ.S., İnceboz T., Korkmaz M., Gümürdülü D. Use of the ELISA (Em2-Em18) and Western blotting methods on diagnosis of alveolar echinococcosis. Turkiye Parazitol. Derg. 2019;43:13–17. doi: 10.4274/tpd.galenos.2019.6447.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hotz J.F., Peters L., Kapp-Schwörer S., Theis F., Eberhardt N., Essig A., Grüner B., Hagemann J.B. Evaluation of serological markers in alveolar echinococcosis emphasizing the correlation of PET-CTI tracer uptake with recEm18 and echinococcus-specific IgG. Pathogens. 2022;11:239. doi: 10.3390/pathogens11020239.</mixed-citation><mixed-citation xml:lang="en">Hotz J.F., Peters L., Kapp-Schwörer S., Theis F., Eberhardt N., Essig A., Grüner B., Hagemann J.B. Evaluation of serological markers in alveolar echinococcosis emphasizing the correlation of PET-CTI tracer uptake with recEm18 and echinococcus-specific IgG. Pathogens. 2022;11:239. doi: 10.3390/pathogens11020239.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">He Z, Yan T, Yuan Y, Yang D, Yang G. miRNAs and lncRNAs in Echinococcus and Echinococcosis. Int J Mol Sci. 2020 Jan 22;21(3):730. doi: 10.3390/ijms21030730.</mixed-citation><mixed-citation xml:lang="en">He Z, Yan T, Yuan Y, Yang D, Yang G. miRNAs and lncRNAs in Echinococcus and Echinococcosis. Int J Mol Sci. 2020 Jan 22;21(3):730. doi: 10.3390/ijms21030730.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Knapp J, Lallemand S, Monnien F, Felix S, Courquet S, Umhang G, Millon L. Real-time multiplex PCR for human echinococcosis and differential diagnosis. Parasite. 2023;30:3. doi: 10.1051/parasite/2023003. Epub 2023 Jan 25.</mixed-citation><mixed-citation xml:lang="en">Knapp J, Lallemand S, Monnien F, Felix S, Courquet S, Umhang G, Millon L. Real-time multiplex PCR for human echinococcosis and differential diagnosis. Parasite. 2023;30:3. doi: 10.1051/parasite/2023003. Epub 2023 Jan 25.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Fan H., Gai W., Zhang L., Ma Y., Wang H., Chen X., Dong J., Zhang Y., Bao H., Zhou Y., et al. Parasite circulating cell-free DNA in the blood of alveolar echinococcosis patients as a diagnostic and treatment-status indicator. Clin. Infect. Dis. 2021;73:e246-e251. doi: 10.1093/cid/ciaa1679.</mixed-citation><mixed-citation xml:lang="en">Fan H., Gai W., Zhang L., Ma Y., Wang H., Chen X., Dong J., Zhang Y., Bao H., Zhou Y., et al. Parasite circulating cell-free DNA in the blood of alveolar echinococcosis patients as a diagnostic and treatment-status indicator. Clin. Infect. Dis. 2021;73:e246-e251. doi: 10.1093/cid/ciaa1679.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Schneider R., Gollackner B., Edel B., Schmid K., Wrba F., Tucek G., Walochnik J., Auer H. Development of a new PCR protocol for the detection of species and genotypes (strains) of Echinococcus in formalin-fixed, paraffinembedded tissues. Int. J. Parasitol. 2008;38:10651071. doi: 10.1016/j.ijpara.2007.11.008.</mixed-citation><mixed-citation xml:lang="en">Schneider R., Gollackner B., Edel B., Schmid K., Wrba F., Tucek G., Walochnik J., Auer H. Development of a new PCR protocol for the detection of species and genotypes (strains) of Echinococcus in formalin-fixed, paraffinembedded tissues. Int. J. Parasitol. 2008;38:10651071. doi: 10.1016/j.ijpara.2007.11.008.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia L.S., Brucner D.A.. In L.S.Garcia, D.A.Brucner (ed.), Diagnostic medical parasitology, 3rd ed. ASM Press Washington, D.C. 1997:387-401.</mixed-citation><mixed-citation xml:lang="en">Garcia L.S., Brucner D.A.. In L.S.Garcia, D.A.Brucner (ed.), Diagnostic medical parasitology, 3rd ed. ASM Press Washington, D.C. 1997:387-401.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Reinehr M, Micheloud C, Grimm F, et al. Pathology of Echinococcosis: a morphologic and immunohistochemical study on 138 specimens with focus on the differential diagnosis between cystic and alveolar echinococcosis. Am J Surg Pathol. 2020;44(1):43-54. doi: 10.1097/PAS.0000000000001374.</mixed-citation><mixed-citation xml:lang="en">Reinehr M, Micheloud C, Grimm F, et al. Pathology of Echinococcosis: a morphologic and immunohistochemical study on 138 specimens with focus on the differential diagnosis between cystic and alveolar echinococcosis. Am J Surg Pathol. 2020;44(1):43-54. doi: 10.1097/PAS.0000000000001374.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Barth T.F.E., Herrmann T.S., Tappe D., Stark L., Gruner B., Buttenschoen K., Hillenbrand A., Juchems M., Henne-Bruns D., Kern P., et al. Sensitive and specific immunohistochemical diagnosis of human alveolar echinococcosis with the monoclonal antibody Em2G11. PLoS Negl. Trop. Dis. 2012;6:e1877. doi: 10.1371/journal.pntd.0001877.</mixed-citation><mixed-citation xml:lang="en">Barth T.F.E., Herrmann T.S., Tappe D., Stark L., Gruner B., Buttenschoen K., Hillenbrand A., Juchems M., Henne-Bruns D., Kern P., et al. Sensitive and specific immunohistochemical diagnosis of human alveolar echinococcosis with the monoclonal antibody Em2G11. PLoS Negl. Trop. Dis. 2012;6:e1877. doi: 10.1371/journal.pntd.0001877.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Reinehr M., Micheloud C., Grimm F., Kronenberg P.A., Grimm J., Beck A., Nell J., Meyer Zu Schwabedissen C., Furrer E., Müllhaupt B., et al. Pathology of Echinococcosis: A Morphologic and Immunohistochemical Study on 138 Specimens with Focus on the Differential Diagnosis Between Cystic and Alveolar Echinococcosis. Am. J. Surg. Pathol. 2020;44:43–54. doi: 10.1097/PAS.0000000000001374.</mixed-citation><mixed-citation xml:lang="en">Reinehr M., Micheloud C., Grimm F., Kronenberg P.A., Grimm J., Beck A., Nell J., Meyer Zu Schwabedissen C., Furrer E., Müllhaupt B., et al. Pathology of Echinococcosis: A Morphologic and Immunohistochemical Study on 138 Specimens with Focus on the Differential Diagnosis Between Cystic and Alveolar Echinococcosis. Am. J. Surg. Pathol. 2020;44:43–54. doi: 10.1097/PAS.0000000000001374.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
