medparasitologyМедицинская паразитология и паразитарные болезниMedical Parasitology and Parasitic Diseases0025-83262713-1777Научно-образовательный паразитологический центр им. П.Г. Сергиева10.33092/0025-8326mp2024.4.52-56medparasitology-63Research ArticleОБЗОРREVIEWНекоторые аспекты эпигенетических механизмов антигенной изменчивости малярийных паразитовSome epigenetic aspects of the mechanisms of antigenic variability of malarial parasitesСахароваТ. В.SakharovaT. V.

Москва

Moscow

ЛаринаС. Н.LarinaS. N.

Москва

Moscow

РаковаВ. М.RakovaV. M.

Москва

Moscow

ПолуэктоваВ. Б.PoluektovaV. B.

Москва

Moscow

ИвановаЕ. Д.IvanovaE. D.

Москва

Moscow

МалинС. С.MalinS. S.

Москва

Moscow

ШидловскийЮ. В.ShidlovskiiY. V.

Москва

Moscow

ЧебышевН. В.ChebyshevN. V.

Москва

Moscow

ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет), кафедра биологии и общей генетикиSechenov First Moscow State Medical Univesity, Department of Biology and General GeneticsФГБОУ ВО МГАВМиБ - МВА им. К.И. Скрябина; РМАНПО Минздрава РФFederal State Budgetary Educational Institution of Higher Education “Moscow state Academy of Veterinary Medicine and Biotechnology - MVA by K.I. Skryabin”; RMA of Continuous Professional Education202427042026045257Copyright © Научно-образовательный паразитологический центр им. П.Г. Сергиева, 20262026Научно-образовательный паразитологический центр им. П.Г. СергиеваНаучно-образовательный паразитологический центр им. П.Г. Сергиеваhttps://www.medparasitology.com/jour/about/submissions#copyrightNoticehttps://www.medparasitology.com/jour/article/view/63

В статье представлены современные данных по изучению генетических адаптаций в системе паразитхозяин при малярии человека. В частности, работа посвящена анализу некоторых эпигенетических механизмов антигенной изменчивости плазмодиев, обеспечивающих их выживаемость и адаптацию в организме хозяина. Понимание этих механизмов может дать представление о разработке новых стратегий лечения и профилактики малярии.

The article presents current data on the study of genetic adaptations in the parasite-host system in human malaria. In particular, the work is devoted to the analysis of some epigenetic mechanisms of antigenic variability of plasmodia, that ensure their survival and adaptation in the host organism. Understanding of these mechanisms may provide insights into the development of new strategies for the treatment and prevention of malaria.

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The authors declare that there are no conflicts of interest present.