The comparative antiparasitic activity of disinfectants from various chemical groups

The antiparasitic activity of 40 disinfectants belonging to different groups of chemicals has been studied. Comparative tests were carried out in parallel using accepted and modified methods of parasitic research.
The studies allowed us to confirm the effectiveness of only 25 % of disinfectants with the declared antiparasitic activity, including disinfectants based on complex compound of iodine, oxygen-active, chloroactive, iodoactive compounds, and based on cationic surfactants in the prolonged exposure mode.
The data on incomplete compliance with the antiparasitic activity of 75 % of disinfectants has been obtained. The most active chemical compounds against parasites have been identified. The accumulated experience in this field of scientific research allows us to identify promising areas of methodological formulation in the development of the disinfection expertise of chemicals that ensure compliance with the criteria for assessing the antiparasitic activity of disinfectants.

1. Sergiev V.P. Registration and real spread of parasitic diseases. Medical parasitology and parasitic diseases. 1991; 2: 3-6. (in Russian)

2. Sergiev V.P., Kuznetsova K.U. Modern problems in the scope of parasitic diseases and their therapy. Infectious diseases: news, opinions, study. 2014; 1: 12-16 p. (in Russian)

3. Genis D.E. Medical parasitology. M.: Medicine. 1991: 240 (in Russain).

4. Anderson R.C. Nematode Parasites of Vertebrates.Their Development and Transmission. - CABI Publishing, 2000: 671.

5. Nappi A.J., Vass E. Parasites of Medical Importance // Georgetown, Texas: Landes Bioscience, 2002: 156.

6. Satoskar A. R., Simon G.L., Hotez P.J., Tsuji M. Medical Parasitology // Landes Bioscience, 200: 319.

7. Shinkarenko A.N. Ecology of dogs parasites and ways of dealing with the diseases caused by them in Nizhnee Povolzhie. Ivanovo 2005: 53 (in Russian).

8. Shulyak B.F., Arkhipov I.A. Nematodosis of dogs (zoonoses and zooanthroponosis). M.: ConsoMed, 2010: 495 (in Russian).

9. Arсhipov I.A., Avdanina D.A., Lihotina S.V. Dogs and cats helminthiasis in large metropolises // Veterinary. 2006; 3: 33-38 (in Russian).

10. Bittirov A.K., Kazancheva L.K., Atalaev M.M., Sarbasheva M.M. Bio- and geohelminthiasis of wild carnivorous in the region of North Caucasus and the improvement of dehelmontational methods // Vestnik KrasGAU. 2010; 1: 112-117.(in Russian).

11. Dolbin, D.A. Khairullin R.Z. Resistance of helminth eggs to unfavorable physical, chemical and biological factors of the environment (literature review) // Russian Journal of Parasitology. - 2017; 39(1): 14-19. (in Russian).

12. Dolbin, D.A. Khairullin R.Z. Analysis of the effectiveness of the use of modern means for disinvasion // Bull of the Kaz Techn Univ. 2015; 18(16): 314-315. (in Russian).

13. Hutoryanina I.V., Dimidova L.L., Khromenkova E.P., Tverdokhlebova T.I. Methods and means of disinfection of environmental objects // The health of the population and habitat. 2018; 3:54–56 (in Russian).

14. Masalkova, Yu.Yu. Disinfection activity of chemicals and drugs in relation to eggs Toxocara canis // Veterinary medicine. 2016; 3: 30-33. (in Russian).

15. Neprimerova T.A., Sivkova T.N. Ovocidal and larvocidal properties of some disinfectants // Materials of reports of the international scientific conference "Theory and practice of combating parasitic diseases". Moscow, 2012; 13: 277-280. (in Russian).

16. Stybel V.V., Pryima O.B., Danko N.N., Svarchevsky O.A. Influence of the disinfectant "Bi-des" on the embryogenesis of Toxocara canis // Scientific Bulletin of LNUVMB im. S.Z. Gzhitsky. 2016; 1-1 (65): 177-181 (in Russian).

17. Yuskiv, I.D. The effectiveness of using various test cultures of helminth eggs to establish the disinvasive properties of chemical agents // Bulletin of the Poltava State Agrarian Academy. 2015; 4 (in Russian).

18. Pautova E.F., Dovgalev A.S., Shchuchinova L.D., Alyautdina L.V. Effect of disinfectants on Toxocara canis eggs (results of experimental studies) // Med. parazitol (Mosk). 2013; 4: 27-29. (in Russian).

19. Pautova E.A. Epizootological, epidemic and ecological aspects of toxocariasis in the Altai Republic: specialty 03.02.11 "Parasitology": dissertation for the degree of candidate of biological sciences; Gorno-Altai State University. Gorno-Altaysk, 2016: 179 (in Russian).

20. Shchuchinova L.D., Pautova E.A., Dovgalev A.S. Effect of household chemicals on the invasive eggs of Toxocara canis // Med. parazitol (Mosk). 2013; 4: 30-32. (in Russian).

21. Lutfullin M.Kh., Lutfullina N.A., Dolbin D.A. Ovocidal effect of chemotherapy on eggs of nematodes of the Strongylata suborder // Scientific Notes of the N.E. Bauman Kazan State Academy of Veterinary Medicine. 2015; 224(4): 122-125 (in Russian).

22. Safiullin R.T., Shibitov S.K. Disinfection of environmental objects against cysts of parasitic protozoa (Buxtonella sulcata) of cattle // Rus parasit j. 2019; 13(1): 64-74 (in Russian).

23. Patent № 2727519 Russian Federation, IPC A61L 2/18, A01N 25/02, A01N 59/12, A61L 101/06, A61L 101/36. Means for disinfestation of objects of the external environment: №2020107067: apl. 16.02.2020: pub. 22.07.2020 / Shibitov S.K; patentee of Scientific Center for Veterinary Parasitology and Therapy LLC) (in Russian).

24. Novikov N.L. Development of means and methods for disinfecting livestock buildings from pathogens of invasive and infectious diseases: specialty 03.00.19 «Parasitology»: diss.. candidate of vet. sciences; All-Russian Scientific Research Institute of Helminthology named after K.I. Scriabin. Moscow, 2004: 145 (in Russian).

25. SP 1.3.2322-08. "Safety of working with microorganisms of III - IV groups of pathogenicity (hazard) and pathogens of parasitic diseases." (in Russian).

26. Patent № 2748168 RF, IPCA01N 25/02, A01N 33/04, A01N 35/02 Means for disinfestation of objects of the external environment: №2020129699: apl. 09.09.2020: pub. 20.05.2021 / Safiullin R.T., Arisov M.V, Shibitov S.K., patentee FSBSI FSC AIEV RAS) (in Russian).

27. Dakhno I.S., Negreba Yu.V., Dakhno G.F. Screening of preparations for disinvasion of environmental objects // Materials of reports of the international scientific conference "Theory and practice of combating parasitic diseases". Moscow, 2010; 11: 144-147. (in Russian).

28. Phakadze T.Y. Antiseptics and disinfectants in nosocomical infections prevention // Clinical microbiology and antimicrobic chemotherapy 2002; 4: 42-48 (in Russian).

29. Fedorova L.S. The choice of disinfectants for a medical organization. // Main nurse. Sanitary and epidemiological regime. 2016; 9 (in Russian).