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Indicators of the hepatobiliary system functions in chronic opisthorchiasis patients with a genetic predisposition to lipid metabolism disturbances
https://doi.org/10.33092/0025-8326mp2023.4.22-29
EDN: CMPBUY
Abstract
To assess the influence of genetic features of metabolic processes on the reactivity to opisthorchiasis invasion, biochemical parameters of the hepatobiliary system functions were studied in chronic opisthorchiasis patients with and without mutant alleles of polymorphisms associated with lipid metabolism disorders were studied. It was found that the presence of mutations in the loci rs2854117 APOC3, rs7412 APOE enhances the negative impact of chronic opisthorchiasis invasion on the state and function of hepatocytes. The presence of the rare allele rs11206510 PCSK9 prevents an increase in ALP activity. In subgroups with mutations in individual polymorphisms of the APOE, APOC3I, ABCA1, lipoprotein lipase, and paraoxanase-1 genes, differences were found in the change in parameters after anthelmintic therapy, possibly associated with their role in the response of metabolic processes not only to invasion, but also to the treatment process.
About the Authors
I. V. Bakshtanovskaya
Tyumen Infection Pathology Research Institute.
Russian Federation
Russian Federation
K. B. Stepanova
Tyumen Infection Pathology Research Institute.
Russian Federation
Russian Federation
A. N. Ozerova
Tyumen Infection Pathology Research Institute.
Russian Federation
Russian Federation
T. F. Stepanova
Tyumen Infection Pathology Research Institute.
Russian Federation
Russian Federation
E. A. Zmatrakova
Tyumen Infection Pathology Research Institute.
Russian Federation
Russian Federation
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Review
For citations:
Bakshtanovskaya I.V., Stepanova K.B., Ozerova A.N., Stepanova T.F., Zmatrakova E.A. Indicators of the hepatobiliary system functions in chronic opisthorchiasis patients with a genetic predisposition to lipid metabolism disturbances. Medical Parasitology and Parasitic Diseases. 2023;(4):22-29. (In Russ.) https://doi.org/10.33092/0025-8326mp2023.4.22-29. EDN: CMPBUY
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