Actual issues of multicriterial PCR analysis in parasitology

The relevance of the study is based on the scientific generalization of modern approaches to technological methods for improving parasitological determinations in potentially hazardous materials from the population's habitat and decisions on the modernization of laboratory activities in the parasitological profile as part of the regulatory regulation of biological safety in the Russian Federation.

Materials and methods. An analysis of more than 12 peer-reviewed sources from Russian and foreign scientific research and 10 sources of legal regulation was conducted to review and substantiate the concept of multi-criteria assessment of parasitological safety in the state control system.

Research objective: Analysis of modern technologies for assessing the effectiveness of laboratory research based on multi-criteria PCR analysis in parasitology.

Conclusions. Modern methodological approaches to promising forms of research quality management have been updated based on the development of effective technologies for parasitological control of environmental and public biosecurity in order to achieve the national development goals of the Russian Federation

1. Sergiev V.P., Kuznetsova K.Yu. Modern problems in the field of parasitic diseases and their therapy // Infectious diseases: news, opinions, training. 2014; 1:12-14 (in Russian)

2. Briko N.I., Onishchenko G.G., Pokrovsky V.I. Handbook of the epidemiology of infectious diseases: in 2 volumes // M.: MIA. - 2019; 880. (in Russian)

3. Wen H., Vuitton L., Tuxun T., Li J., Vuitton D.A., Zhang W., McManus D.P. Echinococcosis: Advances in the 21st Century // Clin Microbiol Rev. 2019; 32(2): e00075-18. DOI: 10.1128/CMR.00075-18.

4. Romig T., Ebi D., Wassermann M. Taxonomy and molecular epidemiology of Echinococcus granulosus sensu lato // Vet Parasitol 2015; 213: 76-84. DOI: 10.1016/j.vetpar.2015.07.035

5. Dimidova L.L., Chernikova M.P., Khutoryanina I.V., Kalyuzhina M.A., Tverdokhlebova T.I. Incidence of larval helminthiasis in the population of the Russian Federation // Theory and practice of combating parasitic diseases. 2022; 23: 184-189. (in Russian)

6. Kuznetsova K.Yu. Scientific substantiation of the system of ensuring parasite safety of the population and the environment on the territory of the Russian Federation: abstract of the dissertation ... Doctor of Medical Sciences: 3.2.1.; 1.5.17. Mytishchi: 2023. 48 p. (in Russian)

7. Guidelines for drinking-water quality, 4th ed. WHO.

8. Krylov M.V. Identification of parasitic protozoa (humans, domestic animals and agricultural plants) // St. Petersburg: ZIN. 1996: 602 p. (in Russian)

9. Pomari E., Piubelli C., Perandin F., Bisoffi Z. Digital PCR: a new technology for diagnosis of parasitic infections // Clin Microbiol Infect. 2019; 25(12): 1510-1516. DOI: 10.1016/j.cmi.2019.06.009.

10. Morozov E.N. Prospects for the application of molecular parasitology methods in monitoring socially significant parasitoses: specialty 03.02.11 "Parasitology": dissertation for the degree of Doctor of Medical Sciences // Moscow, 2018. 189 p. (in Russian)

11. Rezai J. Die Methode, multikriterielle Entscheidungen zu treffen, ist die bestedie schlechteste-Methode: einige Eigenschaften und ein lineares Modell // Omega. 2016; 64: 126-130. (in German). DOI: 10.1016/j.omega.2015.12.001.

12. Geoffrion A.M., Dyer J.S., Feinberg A. An Interactive Approach for Multi-Criterion Optimization, with an Application to the Operation of an Academic Department // Management Science. 1972; 19(4): 457-368. DOI: 10.1287/mnsc.19.4.357

13. Ehrgott M. Gandibleux X. Multiobjective Combinatorial Optimization – Theory, Methodology, and Applications // Multiple Criteria Optimization: State of the Art Annotated Bibliographic Surveys. International Series in Operations Research & Management Science. 2003; 52: 69-444. doi:10.1007/0-306-48107-3_8.