Role in the organization of emergent states of the «parasite-host» system in superinvasive opistorchiasis

The article presents materials on the formation of emergent states of the "parasite–host" system in superinvasive opisthorchiasis (SO) under the influence of endogenous signaling molecules. The original scheme of endometriosis in OS is presented, the morphogenesis of uterine leiomyomas is traced as a result of exclusively endogenous signaling molecules, the development of endometrial cancer is traced without connection with the development of ectopic endometrium. The patho– and morphogenesis of cholangioectases of intra– and extramural bile ducts is presented.

1. Katanugina A.S., Lin'kova N.S., Polyakova V.O., Kvetnoj I.M. Proteins AIF, CREB, CGRP – signal molecules of age–related pathology // Advances in modern biology. 2011. Vol. 131. № 6. P. 543–547.

2. Gioeva F.K. The role of motor proteins in signal transmission // Biochemistry. 2014. Vol. 79. № 9. P. 1061–1069.

3. Soldatov V.M., Kozlov K.L., Lin'kov N.S. Age–related features of the expression of signaling molecules in the endometrium of human vessels and their role in the development of cardiovascular pathology // Molecular medicine. 2015. № 6. P. 33–37.

4. Murtazina A.R., Nikishina Yu.O., Bondarenko N.S. et al. Signal molecules in organism development: central and peripheral sources in ontogeny // Reports of the Academy of Sciences. 2016. Vol. 466. № 6. P. 730–733.

5. Grigoryan I.Yu., Lin'kova N.S., Polyakova E.M. et al. Signal molecules of the endometrium. Gerontological and general pathological aspects // Advances in Gerontology. 2015. Vol. 28. № 3. P. 453–461.

6. Gomazkov O.A. Signaling molecules as regulators of neurogenesis in the adult brain // Neurochemistry. 2013. Vol. 30. № 4. P. 273–288.

7. Gorina Ya.V., Komleva Yu.K., Lopatina O.L. et al. Expression of molecules–components of insulin– mediated signal transduction in brain cells in experimental Alzheimer's disease // Annals of clinical and experimental neurology. 2019. Vol. 13. 4. P. 28–37.

8. Parnova R.G. Lipids as signaling platforms and signaling molecules // Journal of evolutionary biochemistry and physiology. 2020. Vol. 56. № 7. P. 824–825.

9. Uruzbaev R.M., Khadieva E.D., Zharkov N.V. et al. Pathomorphology of the pancreas in superinvasive opisthorchiasis // Ulyanovsk biomedical journal. 2021. № 4. P. 100–112. DOI 10.34014/2227-1848-2021-4-100-112.

10. Uruzbaev R.M. Influence of titanium nickelide alloy supernatant on the regenerative capacity of the skin of Syrian hamsters / Proceedings of the XVIII International Scientific and Practical Conference "Fundamental and Applied Research in the Modern World". Saint Petersburg. 2017. P. 166–174.

11. L'vova M.N., Duzhak T.G., Centalovich Yu.P. et al. The secretom of marita of the liver fluke Opisthorchis felineus // Parasitology. 2014. Vol. 48. № 3. P. 169–184.

12. Paharukova M.Yu. Structural and functional organization of the xenobiotic metabolism system in the pathogen of opisthorchiasis Opisthorchis felineus (Rivolta, 1884): dissertation abstract for the degree of Doctor of Biological Sciences: 03.01.03 – molecular biology. Novosibirsk. 2016. 40 p.

13. Patent № 2748382 C1 Russian Federation, IPC A61B 5/107, G01N 1/28, G01N 1/30. A method for studying the effect of the Opisthorchis felineus secretome component granulin on the formation of new pancreatic islets : № 2020135764 : application 29.10.2020 : published 25.05.2021 / Uruzbaev R.M., Bychkov V.G., Khadieva E.D., Morozov E.N. – EDN ISRHGG.

14. Patent № 2757159 C1 Russian Federation, IPC A61B 5/00, A61D 7/00, G01N 33/567. Method for studying the effect of Opisthorchis felineus exometabolites on proliferative activity and differentiation of kidney stem cells in experiment : № 2020140587 : application 08.12.2020 : published 11.10.2021 / Uruzbaev R.M., Bychkov V.G., Vikhareva L.V. – EDN GRFPNW.

15. Lazarev S.D. Features of liver regeneration after partial hepatectomy against the background of superinvasive opisthorchiasis (experimental study): Abstract for the degree of candidate of medical sciences. Tyumen. 2022. 21 p.

16. Pal'cev M.A., Kvetnoj I.M., Polyakova V.O. et al. Signal molecules in the buccal epithelium: optimization of the diagnosis of socially significant diseases // Molecular Medicine. 2012. № 4. P. 18–22.

17. Pal'cev M.A., Belushkina N.N., Chaban E.E. 4P – medicine as a new model of health care in the Russian Federation // Journal for continuing medical education. 2015. № 2. P. 48–53.

18. Afanas'eva M.H., Bolotskih V.M., Polyakova V.O. Signal molecules as biomarkers for predicting premature rupture of amniotic fluid (clinical and diagnostic aspects) // Journal of Obstetrics and Women's Diseases. 2016. Vol. LXV. № 6. P. 19–27.

19. Zhmurov V.A., Nalobin A.V., Nalobin V.A. Indicators of lipid peroxidation of cell membranes and the state of antioxidant systems in patients with opisthorchiasis / Diagnosis and treatment of diseases of the liver, pancreas, spleen and duodenum. Tyumen. 1987. P. 180–181.

20. Bychkov V.G., Simonov A.V., Khadieva E.D. et al. Endometriosis: cyto- and morphogenesis of ectopic endometrium / Proceedings of the V Congress of the Russian Society of Pathologists with International Participation. Chelyabinsk. 2017, pp. 57–58.

21. Bychkov V.G., Molokova O.A., Khadieva E.D. et al. Dishormonal pathology of women with superinvasive opisthorchiasis: endometriosis, endometrioid cancer and leiomyoma / Materials of the IV All-Russian scientific and practical conference with international participation "Modern methods for the morphological diagnosis of human neoplasms". Chelyabinsk. 2019. P. 12–15.

22. Milovanov A.P., Voloshchuk I.N. Deported syncytiotrophoblast and placental microparticles in a mother during normal pregnancy and preeclampsia (28 years later) // Archive of pathology. 2017. № 1. P. 61–67.

23. Dilman V.M. Four models of medicine. Leningrad. Medicine. 1987. 287 p.

24. Hutadiloc N., Thamavit W., Upatam E.S. et al. Liver procollagen prolylhydroxylase in opisthorchis viverrini infected hamster praziguantel administration. // Mol. Biohim Parasitol. 1983. Vol. 9. № 4. P. 289–295.

25. Horst A. Molecular pathology. 1967. 376 p.

26. Hashkhozhaeva D.A., Sunsheva B.M., Paritov A.Yu., Pashtova L.R. Molecular physiology. 2018. 112 p.

27. Zyuganov V.V. The paradox of a parasite prolonging the life of its host. Pearl mussel Margaritifera margaritifera turns off accelerated aging program for salmon Salmo salar // Reports of the Academy of Sciences. 2005. Vol. 403. № 5. P. 701–705.

28. Sejc I.F., Knyazev P.G. Molecular oncology. 1986. 352 p.