Human dracunculiasis - a rare tropical helminthiasis

The review presents current data on the epidemiology, diagnosis, interaction between the parasite and the host, the pathology of dracunculiasis with a description of rare cases of atypical course of the disease. The current status and future prospects for vector control and elimination strategies are also described. The information collected in this article is presented to raise the awareness of medical professionals in order to quickly diagnose and effectively treat patients, as well as to prevent invasion of both humans and animals.

1. Sergiev V.P. Atlas of Clinical Parasitology and Tropical Medicine // Dracunculosis. 2010:200-201. (in Russian).

2. Prashanth Rawla, Arif Jan. Dracunculiasis // Book. Oct 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.

3. Carmen Pellegrino, Giulia Patti, Michele Camporeale, Alessandra Belati. Guinea Worm Disease: A Neglected Diseases on the Verge of Eradication // TropMedInfectDis. 2022;7(11):366. DOI: 10.3390/tropicalmed7110366.

4. Cleveland C.A., Eberhard M.L., Thompson A.T., Smith S.J., Zirimwabagabo H., Bringolf R., Yabsley M.J. Possible Role of Fish as Transport Hosts for Dracunculus spp. larvae // Emerg. Infect. Dis. 2017;23:1590–1592. DOI: 10.3201/eid2309.161931.

5. Eberhard M.L., Ruiz-Tiben E., Hopkins D.R., Farrell C., Toe F., Weiss A., Withers P.C., Jr., Jenks M.H., Thiele E.A., Cotton J., et al. The Peculiar Epidemiology of Dracunculiasis in Chad / Am. J. Trop. Med. Hyg. 2014;90:61–70. DOI: 10.4269/ajtmh.13-0554.

6. Molyneux D., Sankara D.P. Guinea worm eradication: Progress and challenges — Should we beware of the dog? // PLOS Negl. Trop. Dis. 2017;11:e0005495. DOI: 10.1371/journal.pntd.0005495.

7. Hopkins D.R., Ruiz-Tiben E. Strategies for dracunculiasis eradication. Bull // World Health Organ. 1991;69:533–540.

8. World Health Organization (WHO) The Road to 2030. WHO 5 July 2022 - https://www.who.int/teams/control-of-neglected-tropicaldiseases/dracunculiasis/global-epidemiology (Дата обращения: 01 мая 2023 года).

9. Netshikweta R., Garira W. A Multiscale Model for the World's First Parasitic Disease Targeted for Eradication: Guinea Worm Disease // Comput Math Methods Med. 2017:1473287. DOI: 10.1155/2017/1473287.

10. Tayeh A., Cairncross S., Cox F.E.G. Guinea worm: From Robert Leiper to eradication // Parasitology. 2017;144:1643–1648. DOI: 10.1017/S0031182017000683.

11. Donald R Hopkins, Adam J Weiss, Sarah Yerian, Sarah G H Sapp, Vitaliano A Cama. Progress Toward Global Eradication of Dracunculiasis // MMWR Morb Mortal Wkly Rep. 2022;71(41):1496-1502. DOI: 10.15585/mmwr.mm7147a2.

12. Michele B. The Tail End of Guinea Worm — Global Eradication without a Drug or a Vaccine // New England Journal of Medicine. 2007;356(25):2561–2564.

13. Netshikweta R., Garira W. A Multiscale Model for the World’s First Parasitic Disease Targeted for Eradication: Guinea Worm Disease // Comput. Math. Methods Med. 2017;2017:1473287. DOI: 10.1155/2017/1473287.

14. Hopkins D.R., Ijaz K., Weiss A.J., Roy S.L. Certifying Guinea worm eradication in humans and animals // Lancet. 2021;397:793–794. DOI: 10.1016/S0140-6736(21)00262-2.

15. Centers for Diseases Control (CDC) Guinea Worm Wrap-Up Archive - https://www. cdc.gov/parasites/guineaworm/wrap-up/index. html (Дата обращения: 01.05.2023 года)

16. Burki T. Countries recommit to Guinea worm eradication by 2030 // Lancet Infect. Dis. 2022;22:597–598. DOI: 10.1016/S1473-3099(22)00239-0.

17. Pichakacheri S. Guinea-worm (Dracunculus medinensis) infection presenting as a diabetic foot abscess: A case report from Kerala // Natl. Med. J. India. 2019;32:22. DOI: 0.4103/0970-258X.272111.

18. Rawla P., Jan A. StatPearls Publishing; Treasure Island, FL, USA: 2022. Dracunculiasis. 2022 May 29.

19. Visser B.J. Dracunculiasis eradication - Finishing the job before surprises arise. Asian Pac // J. Trop. Med. 2012;5:505–510. DOI: 10.1016/S1995-7645(12)60088-1.

20. Awofeso N. Towards global Guinea worm eradication in 2015: The experience of South Sudan // Int. J. Infect. Dis. 2013;17:e577–e582. DOI: 10.1016/j.ijid.2013.03.003.

21. World Health Organization (WHO) Dracunculiasis Eradication: Global Surveillance Summary, 2021. - Available online: https://www.who.int/publications/i/item/whower9721-22-225-247 (Дата обращения: 01.05.2023 года)

22. Galán-Puchades M. Dracunculiasis: Water-borne anthroponosis vs. food-borne zoonosis // J. Helminthol. 2019;94:e76. DOI: 10.1017/S0022149X19000713.

23. McLaughlin G.E., Utsinger P.D., Trakat W.F., Resnick D., Moidel R.A. Rheumatic syndromes secondary to guinea worm infestation // Arthritis Care Res. 1984;27:694–697. DOI: 10.1002/art.1780270614.

24. Darkase B.A., Ratnaprkhi T., Bhatt K., Khopkar U. Unusual cutaneous manifestations of dracunculiasis: Two rare case reports // Indian J. Dermatol. Venereol. Leprol. 2021:1-4. DOI: 10.25259/IJDVL_909_20.

25. Boyce M.R., Carlin E.P., Schermerhorn J., Standley C.J. A One Health Approach for Guinea Worm Disease Control: Scope and Opportunities // Trop. Med. Infect. Dis. 2020;5:159. DOI: 10.3390/tropicalmed5040159.

26. Hamilton L.J., Evans A.J. Dracunculiasis: a rare cause of breast calcification detected on screening mammography // Clinical Radiology. 2004;59(2):205–206. DOI: 10.1016/j.crad.2003.09.001.

27. Bin Saleem T., Ahmed I. "Serpent" in the breast // J Ayub Med CollAbbottabad. 2006;18(4).

28. Shannon K. Barry, William Gregory Schucany Dracunculiasis of the Breast: Radiological Manifestations of a Rare Disease // J Radiol Case Rep. 2012;6(11):29–33. DOI: 10.3941/jrcr.v6i11.1137

29. Bhushan Amol Darkase, Tejaswini Ratnaprkhi, Kalpana Bhatt, Uday Khopkar. Unusual cutaneous manifestations of dracunculiasis: Two rare case reports // Indian J Dermatol Venereol Leprol. 2023;89(2):237-240. DOI: 10.25259/IJDVL_909_20

30. Pichakacheri S.K. Guinea-worm (Dracunculus medinensis) infection presenting as a diabetic foot abscess: A case report from Kerala // Natl Med J India 2019;32(1)22-23 DOI: 10.4103/0970-258X.272111

31. Eberhard M.L., Ruiz-Tiben E., Korkor A.S., Roy S.L., Downs P. Emergence of Onchocerca volvulus from Skin Mimicking Dracunculiasis medinensis // Am. J. Trop. Med. Hyg. 2010;83:1348–1351. DOI: 10.4269/ajtmh.2010.10-0475.

32. Mbong E.N., Sume G.E., Danbe F., Kum W.K., Mbi V.O., Fouda A.A.B., Atem P. Not every worm wrapped around a stick is a guinea worm: A case of Onchocerca volvulus mimicking Dracunculus medinensis // Parasites Vectors. 2015;8:374. DOI: 10.1186/s13071-015-1004-1

33. Carranza-Rodríguez C., Pérez-Arellano J.L. Radiological Detection of Dracunculus Medinensis // Am. J. Trop. Med. Hyg. 2018;98:1218–1219. DOI: 10.4269/ajtmh.17-0944.

34. Pallara E., Cotugno S., Guido G., De Vita E., Ricciardi A., Totaro V., Camporeale M., Frallonardo L., Novara R., Panico G.G., et al. Loa loa in the Vitreous Cavity of the Eye: A Case Report and State of Art // Am. J. Trop. Med. Hyg. 2022;1 DOI: 10.4269/ajtmh.22-0274.

35. Lancet T.Guinea worm disease eradication: A moving target // Lancet. 2019;393:1261. DOI: 10.1016/S0140-6736(19)30738-X.

36. Lemma G.W., Müller O., Reñosa M.D., Lu G. Challenges in the last mile of the global guinea worm eradication program // Trop. Med. Int. Health. 2020;25:1432–1440. DOI: 10.1111/tmi.13492

37. Roberts L. Exclusive: Battle to wipe out debilitating Guinea worm parasite hits 10 year delay // Nature. 2019;574:157–158. DOI: 10.1038/d41586-019-02921-w.