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Acanthamoebic keratitis. Case descriptions

https://doi.org/10.33092/0025-8326mp2025.1.53-58

EDN: AUXOLI

Abstract

Timely diagnosis and appropriate therapy are key elements for a good prognosis in Acanthamoeba keratitis (AK). Acanthamoeba keratitis should be considered a corneal injury in almost all contact lens (CL) users. A presumptive diagnosis of Acanthamoeba keratitis can be made clinically with in vivo confocal microscopy, through direct microscopy of tear fluid, corneal scrapings, on histological sections, or using polymerase chain reaction (PCR). The article presents the clinical picture and the application of confocal microscopy in the diagnosis of Acanthamoeba keratitis.

About the Authors

M. S. Maksimova
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation; State Виdgetary Institution «Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Departament»
Russian Federation


E. V. Stepanova
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation; State Виdgetary Institution «Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Departament»
Russian Federation


N. A. Turbabina
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation
Russian Federation


S. A. Gromova
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation
Russian Federation


E. A. Morozovа
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation
Russian Federation


A. A. Dmitriev
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation
Russian Federation


L. F. Morozovа
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation
Russian Federation


A. S. Anikina
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation
Russian Federation


A. V. Kondrashin
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation
Russian Federation


E. N. Morozov
FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation
Russian Federation


References

1. Morbidity rate of the entire population of Russia in 2023: statistical materials M.: Federal State Budgetary Institution "TsNIIOIZ" of the Ministry of Health of Russia 2024: 154 (in Russian).

2. Maichuk D.Y., Chilingaryan L.B., Kishkin Y.I., Maichuk N.V. Surgical treatment of acanthamoebic keratitis by phototherapeutic keratectomy. Problem analysis and clinical case // Ophthalmosurgery. 2010; (6): 51-54 (in Russian).

3. Astakhov Yu.S., Skryabina Ye.V., Konenkova Ya.S., Kasymov F.O., Bogomolova T.S., Pinegina O.N. Diagnosis and treatment of fungal keratitis // Ophthalmological bulletin. 2013; 6(2): 75–80 (in Russian).

4. Skryabina Ye.V., Astakhov Yu.S., Konenkova Ya.S., Varganova T.S., Petukhov V.P., Nokhrina K.V., Dnestryanskaya K.O. Acanthamoeba keratitis. Review of literature. Case reports // Ophthalmology Journal. 2019; 12(1): 59-71 (in Russian) DOI: 10.17816/OV12159-71.

5. Volkov V.V, Gordeeva L.M, Kaminskaia L Iu. Astakhov The diagnosis of Acanthamoeba keratitis. The identification of the first case in Russia // Med Parazitol. 1993; 5: 60-63 (in Russian)

6. Okolov I.N, Chayka N.A, Egorova O.V, et al. Akantameby i akantamebnyy keratit. Posobie dlya vrachey. Ed. by L.I. Balashevich. Saint Petersburg. 2005 (in Russian)

7. Avetisov S.Je., Gordeeva L.M., Grigorjan M.B. Acanthamoebae lesions of the cornea Annals of ophthalmology // Vestnik oftal’mologii. 2001; 117(5): 53-55 (in Russian)

8. Majchuk Ju.F., Majchuk D.Ju. Clinical forms acanthameba keratitis in light of biomicroscopy and confocal microscopy. Annals of ophthalmology // Vestnik oftal’mologii. 2004; 120(1): 45–47 (in Russian)

9. Avetisov S.Je., Kasparov A.A., Marchenko N.R., Fedorov A.A., Kasparova Evg.A., Borodina N.V., Loseva I.E. Acanthameba keratitis – clinical features, diagnosis and treatment. Moscow. 2007: 173-178 (in Russian)

10. Chebyshev N.V. Medical parasitology. Textbook. M.: Medicine, 2012: 33-34 (in Russian).

11. Kasparova E.A., Kasparov A.A., Marchenko N.R., Fedorov A.A., Egorova G.B., Kobzova M.V., Mitichkina T.S. Clinical Features, Diagnosis, the Results of Therapeutic and Surgical Treatment of Acanthamoebic Keratitis // Ophthalmology 2017; 14(4): 306-314 (in Russian) DOI: 10.18008/1816-5095-2017-4-306-314.

12. Lorenzo-Morales J., Khan N.A., Walochnik J. An update on Acanthamoeba keratitis: diagnosis, pathogenesis andtreatment // Parasite. 2015; 22: 10. DOI:10.1051/parasite/2015010.

13. Marchenko N.R., Kasparova E.A. Diagnosis of acanthamoebic keratitis // Bulletin of Ophthalmology. 2016; 132(5): 103-109 (in Russian) DOI: 10.17116/oftal-ma20161325103-109.

14. Garate M., Marchant J., Cubillos I., Cao Z., Khan N., Panjwani N. In Vitro Pathogenicity of Acanthamoeba Is Associated with the Expression of the Mannose-Binding Protein // Invest. Ophthalmol. Vis. Sci. 2006; 47(3): 1056-1062. DOI: 10.1167/iovs.05-0477.

15. Marciano-Cabral F., Carbal G. Acanthamoeba spp. As agents of disease in humans //Clin Microbiol Rev. 2003; 16(2): 273-30. DOI: 10.1128/CMR.16.2.273-307.2003.

16. Bikbov M.M., Surkova V.K., Usubov E.L., Nikitin N.A. Acanthamoeba keratitis and outcomes of the treatment (clinical cases) // Ophthalmology. 2015; 12(4): 80-83 (in Russian) DOI: 10.18008/1816-5095-2015-4-80-83.

17. Gumerova S.G., Marvanova L.R. K voprosu o diagnostike akantamebnogo keratita (klinicheskiy opyt). In: Proceedings of the Scientific and Practical Conference on Ophthalmosurgery with international participation "Vostok-Zapad"; Ufa, 6-7 Jun 2013. Ufa: DizaynPress, 2013: 298 (in Russian).


Review

For citations:


Maksimova M.S., Stepanova E.V., Turbabina N.A., Gromova S.A., Morozovа E.A., Dmitriev A.A., Morozovа L.F., Anikina A.S., Kondrashin A.V., Morozov E.N. Acanthamoebic keratitis. Case descriptions. Medical Parasitology and Parasitic Diseases. 2025;(1):53-58. (In Russ.) https://doi.org/10.33092/0025-8326mp2025.1.53-58. EDN: AUXOLI

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ISSN 0025-8326 (Print)
ISSN 2713-1777 (Online)