The effectiveness of serological diagnosis of hepatic echinococcosis in the early stages of the disease

We observed 16 patients aged 16 to 20 years (Iu = 18 years) with hepatic echinococcosis at an early stage of the disease with a cyst diameter from 14 to 38 mm. Along with radiation diagnostic methods, a serological blood test was performed for the presence of specific antibodies to cystic echinococcosis using the Echinococcus-IgG-EIA-BEST diagnostic kits (Novosibirsk, Russia). In the initial study, the ELISA test was positive in 62.5 % of patients. In 37.5 % of cases, a seronegative course of the disease was observed. Upon repeated examination (after 6 months), positive results were registered in 87.5 % of patients. At the same time, in the group of patients who received only conservative antiparasitic therapy, the ratio of positive results was 100%.

1. Zhavoronok S.V., Mitsura V.M., Kozlov S.S. et al. Human parasitic diseases // Gomel: Without publishing house, 2006; 304 p.

2. Pozdeev O.K., Sabirov R.M., Kozlov S.S. et al. Medical parasitology: helminths: a practical guide // M.: GEOTAR-Media, 2024; 400 p. DOI: 10.33029/9704-7685-7-MPH-2024-1-400.

3. Guerrant R.L., Walker D.H., Weller P.F. Tropical Infectious Diseases: Principles, Pathogens and Practice. 3 edition., Elsevier Inc., 2011; 1143 p.

4. Gorbachev D.S., Kulikov A.N., Kozlov S.S., Kolbin A.A., Voronov A.V., Kudryavtseva A.V., Kovalevskaya I.S., Yakovenko A.I., Burnasheva M.A., Kharitonova N.N., Zemlyanukhin N.V. A clinical case of echinococcosis of the orbit. Modern approaches to diagnosis and treatment // Ophthalmology. 2022; 19(1): 215-228. DOI 10.18008/1816-5095-2022-1-215-228.

5. Ermakova L.A., Tverdokhlebova T.I., Bolatchiev K.Kh., Tsekapibzeva F.K., Kirtanasov Ya.P., Domashenko N.N. Clinical and epidemiological aspects of echinococcosis in some territories of the North Caucasus // Cytokines and inflammation. 2012; 11(3): 65.

6. Adoeva E.Ya., Baranova A.M., Bronstein A.M. et al. Human parasitic diseases (protozoosis and helminthiasis) / Edited by Sergiev V.P., Lobzin Yu.V., Kozlov S.S. – 3rd edition, revised and supplemented. // S-Pb.: Foliant Publishing House, 2016; 640 p.

7. Bazhenov L.G., Tursunov N.T., Kozlov S.S. Possibilities of diagnosing echinococcosis of various localization using enzyme immunoassay // Medical parasitology and parasitic diseases. 2010; 4: 55-57.

8. Brunetti E., Kern P., Vuitton D.A.; Writing Panel for the WHO-IWGE. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans // Acta Trop. 2010; 114(1): 1-16. DOI: 10.1016/j.actatropica.2009.11.001.

9. Tamarozzi F., Silva R., Fittipaldo V.A., Buonfrate D., Gottstein B., Siles-Lucas M. Serology for the diagnosis of human hepatic cystic echinococcosis and its relation with cyst staging: A systematic review of the literature with meta-analysis // PLoS Negl Trop Dis. 2021; 15(4): e0009370. DOI: 10.1371/journal.pntd.0009370.

10. Erganis S., Sarzhanov F., Al F.D., Cağlar K. Comparison of Methods in the Serologic Diagnosis of Cystic Echinococcosis // Acta Parasitol. 2024; 69(2): 1122-1131. DOI: 10.1007/s11686-024-00840-z.