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Indicators of the hepatobiliary system functions in chronic opisthorchiasis patients with a genetic predisposition to the type 2 diabetes mellitus development
https://doi.org/10.33092/0025-8326mp2023.1.3-9
EDN: IBUZDD
Abstract
To assess the influence of genetic features of metabolic processes on the reactivity to opisthorchiasis invasion, biochemical parameters of the hepatobiliary system functions were studied in chronic opisthorchiasis patients with and without mutant alleles of polymorphisms associated with the type 2 diabetes mellitus. It was found that the presence of mutations in the genes PPARG and TCF7L2 (rs12255372), HHEX, IGF2BP2 and SLC30A8 enhances the opisthorchiasis negative impact on the activity of alpha-amylase and indicators of impaired bile secretion. The presence of a rare allele of the IGF2BP2 gene prevents an increase in GGT activity, and the presence of a rare allele of the CDKAL1 and SLC30A8 genes reduces the degree of increase in glucose concentration in opisthorchiasis.
About the Authors
I. V. Bakshtanovskaya
Tyumen Infection Pathology Research Institute
Russian Federation
Russian Federation
K. B. Stepanova
Tyumen Infection Pathology Research Institute
Russian Federation
Russian Federation
A. N. Ozerova
Tyumen Infection Pathology Research Institute
Russian Federation
Russian Federation
T. F. Stepanova
Tyumen Infection Pathology Research Institute
Russian Federation
Russian Federation
E. A. Zmatrakova
Tyumen Infection Pathology Research Institute
Russian Federation
Russian Federation
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Review
For citations:
Bakshtanovskaya I.V., Stepanova K.B., Ozerova A.N., Stepanova T.F., Zmatrakova E.A. Indicators of the hepatobiliary system functions in chronic opisthorchiasis patients with a genetic predisposition to the type 2 diabetes mellitus development. Medical Parasitology and Parasitic Diseases. 2023;(1):3-9. (In Russ.) https://doi.org/10.33092/0025-8326mp2023.1.3-9. EDN: IBUZDD
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