Some epigenetic aspects of the mechanisms of antigenic variability of malarial parasites
https://doi.org/10.33092/0025-8326mp2024.4.52-56
Abstract
The article presents current data on the study of genetic adaptations in the parasite-host system in human malaria. In particular, the work is devoted to the analysis of some epigenetic mechanisms of antigenic variability of plasmodia, that ensure their survival and adaptation in the host organism. Understanding of these mechanisms may provide insights into the development of new strategies for the treatment and prevention of malaria.
About the Authors
T. V. SakharovaRussian Federation
Moscow
S. N. Larina
Russian Federation
Moscow
V. M. Rakova
Russian Federation
Moscow
V. B. Poluektova
Russian Federation
Moscow
E. D. Ivanova
Russian Federation
Moscow
S. S. Malin
Russian Federation
Moscow
Y. V. Shidlovskii
Russian Federation
Moscow
N. V. Chebyshev
Russian Federation
Moscow
References
1. World Health Organization. World Malaria Report 2022. //Med Parazitol. 2017;1-186. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2022.
2. Cortés A, Deitsch KW. Epigenetics of Malaria. //Cold Spring Harb Perspect Med. 2017 июль 5; 7(7):a025528. DOI: 10.1101/cshperspect.a025528. PMID: 28320828; PMCID: PMC5495052.).
3. Kats LM, Fernandez KM, Glenister FK, Herrmann S, Buckingham DW, Siddiqui G, Sharma L, Bamert R, Lucet I, Guillotte M, Mercereau-Puijalon O, Cooke BM. An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells. //Int J Parasitol. 2014 Apr;44(5):319-28. doi: 10.1016/j.ijpara.2014.01.003. Epub 2014 Feb 14. PMID: 24530877.
4. Mira-Martínez, S., van Schuppen, E., Amambua-Ngwa, A., Bottieau, E., Affara, M., van Esbroeck, M., Vlige, E., Geeraerts, P., Rovira-Graells, N., Gómez-Pérez, G.P. et al. Expression of Clag3 genes in clonal variants of Plasmodium falciparum during human infections. //Med Parazitol. 2017;215(6):938-945. Doi: 10.1093/infdis/jix053. https://pmc.ncbi.nlm.nih.gov/articles/PMC9601349/.
5. Cheng Q, Cloonan N, Fischer K, Thompson J, Waine G, Lanzer M, et al. stevor and rif are Plasmodium falciparum Multicopy Gene Families Which Potentially Encode Variant Antigens. Mol Biochem Parasitol (1998) 97:161-76. doi: 10.1016/s0166-6851(98)00144-3.
6. Hollin, T., Gupta, M., Lenz, T., Le Roch, K.G. Dynamic chromatin structure and epigenetics control the fate of malaria parasites. // Med Parazitol. 2021;37(1):73-85. Doi: 10.1016/j. tig.2020.09.003. https://pmc.ncbi.nlm.nih.gov/articles/PMC7755682/.
7. Cui, L., Miao, J., Furuya, T., Li, X., Su, X.Z., & Cui, L. PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum. //Med Parazitol. 2007;6(7):1219-1227. Doi: 10.1128/ec.00063-07. https://journals.asm.org/doi/10.1128/ec.00063-07.
8. Gardner, M.J., Hall, N., Fung, E., White, O., Berriman, M. Et al. Genome sequence of the human malaria parasite Plasmodium falciparum. //Med Parazitol. 2002;419(6906):498-511. https://www.nature.com/articles/nature01097.
9. Anna Barcons-Simon , Mark Carrington , T Nicolai Decoding the impact of nuclear organization on antigenic variation in parasites // Nat Microbiol. 2023 Aug;8(8):1408-1418. doi: 10.1038/s41564-023-01424-9. Epub 2023 Jul 31.
10. Akihito Sakoguchi. Hisashi Arase Mechanisms for Host Immune Evasion Mediated by Plasmodium falciparum //Front. Immunol., 15 June 2022 Sec. Parasite Immunology Volume 13 - 2022 https://translated.turbopages.org/proxy_u/en-ru.ru.65101256-6735143da5940029-74722d776562/https/doi.org/10.3389/fimmu.2022.901864.
11. Curr Opin Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites //Victoria Jeffers Microbiol . 2024 Jun:79:102472. doi: 10.1016/j.mib.2024.102472. Epub 2024 Apr 6.
12. Jeffers, V. Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites. //Med. Parazitol. 2024;79:102472. Doi: 10.1016/j.mib.2024.102472. https://pubmed.ncbi.nlm.nih.gov/38527910/.
13. Jabeena, C.A., Rajavelu, A. Histone globular domain epigenetic modifications: The regulators of chromatin dynamics in malaria parasite. //Med Parazitol. 2024;25(4):e202300596. Doi: 10.1002/cbic.202300596. https://pubmed.ncbi.nlm.nih.gov/38078518/.
14. Amit-Avraham, I., Pozner, G., Eshar, S., Fastman, Y., Kolevzon, N., Yavin, E., Dzikowski, R. Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum. //Med Parazitol. 2015;112(9):E982-91. Doi: 10.1073/pnas.1420855112. https://pmc.ncbi.nlm.nih.gov/articles/PMC4352787/.
15. Serrano-Durán, R., López-Farfán, D., Gómez-Díaz, E. Epigenetic and epitranscriptomic regulation of Plasmodium falciparum genes and how we can leverage it to fight malaria. // Med Parazitol. 2022;13(10):1734. Doi: 10.3390/genes13101734. https://pubmed.ncbi.nlm.nih.gov/36292619/.
16. Hollin, T., Chakrabarti, Z., Le Roch, K.G. Epigenetic regulation and chromatin remodeling in malaria parasites. //Med. Parazitol. 2023;77(3):255-276. Doi: 10.1146/annurevmicro-032521-041554. https://pmc.ncbi.nlm.nih.gov/articles/PMC5495052/.
17. Ralph, S.A., Scheidig-Benatar, C., Scherf, A. Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations. //Med Parazitol. 2005;102(15):5414-9. https://www.pnas.org/doi/full/10.1073/pnas.0408883102.
18. Bunnik, E.M., Venkat, A., Shao, J., McGovern, K.E., Batugedara, G., Worth, D., Prudhomme, J., Lapp, S.A., Andolina, C., Ross, L.S., Lawres, L., Brady, D., Sinnis, P., Nosten, F., Fidock, D.A., Tewari, R., Galinski, M.R., Ben Mamoun, C., Ay, F., Le Roch, K.G. Comparative 3D genome organization in apicomplexan parasites. // Med Parazitol. 2019;116(8):3183-3192. Doi: 10.1073/pnas.1810815116. https://pmc.ncbi.nlm.nih.gov/articles/PMC6386730/.
19. Kaviratne, M., Khan, S.M., Jarra, W., & Preiser, P.R. Small variant STEVOR antigen is uniquely located within Maurer's clefts in Plasmodium falciparum - infected red blood cells. //Med Parazitol. 2002;1(6):926-935. PMID: 12455695; PMCID: PMC130696. https://doi.org/10.1128/EC.1.6.926-935.2002.
20. Recker, M., Buckee, C.O., Serazin, A., Kyes, S., Pinches, R., Christodoulou, Z., & Newbold, C.I. Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern. //Med Parazitol. 2011;7(3):e1001306. https://doi.org/10.1371/journal.ppat.1001306.
Review
For citations:
Sakharova T.V., Larina S.N., Rakova V.M., Poluektova V.B., Ivanova E.D., Malin S.S., Shidlovskii Y.V., Chebyshev N.V. Some epigenetic aspects of the mechanisms of antigenic variability of malarial parasites. Medical Parasitology and Parasitic Diseases. 2024;(4):52-57. (In Russ.) https://doi.org/10.33092/0025-8326mp2024.4.52-56
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