Changes in plasma cells of white rats under experimental infection with trichinellosis

For experimentally infected rats with Trichinella spiralis (Owen, 1835) Railliet, 1895, spleen and bone marrow are shown to play an important role in the host immune responses.

We have studied a role of plasma cells in formation of protective responses for experimental Trichinella infection of white rats. It's been established that a degree of immunological transformation directly depended on a stage of Trichinella spiralis in the host. A stimulating effect of Trichinella has been shown at early intestinal and early muscular stages of the parasite's development. In these periods, high levels of blast cells with mitoses and high number of plasma cells were noticed. A suppressive effect of Trichinella at migration stage was accompanied by decrease of proliferation level and numbers of plasma cells, leading to suppression of the host immune response. Also, a sinusoid-like flow of plasmacytic reaction and mitotic activity of spleen cells had been noted.

During studies of morphological composition of peripheral blood increase in eosinophils' numbers was noted. This fact may be explained by the migration of Trichinella larvae, which may cause defensive reactions in the host (eosinophils are excreted into blood).

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