Indicators of the functions of the hepatobiliary system in patients with chronic opisthrochisis with the presence of genetic polymorphisms associated with a presposition to the development of osteoporosis

To assess the influence of genetic features of metabolic processes in bone tissue on the reactivity of the hepatobiliary system in opisthorchiasis invasion, a study of biochemical parameters was conducted in subgroups of patients with chronic opisthorchiasis with and without mutations in loci associated with a predisposition to the development of osteoporosis. It was found that the presence of a mutation in the rs1544410 locus of the VDR gene enhances the negative impact of chronic opisthorchiasis invasion on bile secretion (increased alkaline phosphatase activity), and in the rs2234693 locus of the ESR1 gene – on the concentration of glucose in the blood. However, the presence of rare alleles associated with a predisposition to osteoporosis in other loci prevents the negative impact of chronic opisthorchiasis on the functions of the hepatobiliary system and pancreas, namely, an increase in the concentration of bilirubin (ESR1 rs2234693, ESR1 rs9340799), activity of AM (ESR1 rs9340799), ALT (LCT rs4988235), GGT and ALP (LCT rs4988235, LRP5 rs3736228). In the group with a mutation in the rs1800012 locus of the COL1 A1 gene, differences in the change in indicators (ALT, AST and GGT activity) after anthelmintic therapy were revealed, possibly associated with the role of collagen in the reaction of metabolic processes not only to invasion, but also to the treatment process.

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